Firefighters were called to University of Chester Academy High School at around 6am yesterday.
12 fire crews from Cheshire Fire and Rescue were called to the school on Shipbrook Road after the fire was reported.
Two engines from Northwich and Winsford, and one from each of Middlewich, Congleton, Sandbach, Holmes Chapel, Lymm, Warrington and Altrincham attended the scene, along with the service's aerial appliance.
The blaze had broken out in two separate roofs of buildings at the school, and has created a lot of visible damage to the roof structure.
Fire crews used several mains jet and hose reels to tackle the fires, and breathing apparatus due to concerns of potential asbestos from the building fabric.
It took firefighters around three hours to bring the blaze under control, with appliances remaining on site for most of the day to dampen the fire down and ensure the site was safe.
The fire is believed to have been started deliberately and Cheshire Police are urging anyone who may have information on the incident to contact them on 101.
Man jailed after admitting causing the death of his girlfriend
Residents invited to help shape the future of Cheshire East
Mobile household waste recycling centre service launches across Cheshire East
Have your say on proposals for the A500 Corridor Improvements Scheme
New primary school for Basford East moves closer as trust appointed
Appeal for information following serious collision in Weston
Man found guilty of sexual assault in Northwich
Congleton residents vote in favour of Neighbourhood Plan
Over 140 vehicles dealt with during Alderley Edge deployments
Update following industrial incident in Aston by Budworth
Cheshire maternity unit boosted by new artwork
Man charged following series of car interferences in Macclesfield
Cheshire East schools back phone-free education with lockable pouches ahead of September
Man jailed after engaging in sexual activity with child in Crewe
New ‘Showstopper’ play tower officially unveiled at West Park in Macclesfield
Man arrested following firearms discharge in Whitegate
Volunteers Celebrate Successful Footpath Clearing Day